Homocysteine, vitamins, and cardiovascular disease.
نویسندگان
چکیده
The significance of any association between cardiovascular disease and circulating homocysteine concentrations is attracting considerable attention. The normal activities of the transsulfuration and remethylation pathways maintain intracellular homocysteine levels within a narrow range, and the controlled release of homocysteine into blood results in blood measurements that provide an accurate index of homocysteine status. In the circulation, homocysteine is rapidly oxidized, and very little homocysteine remains in the reduced form. The majority of homocysteine forms a disulfide bridge with protein, and some reacts either with itself to produce homocystine or with cysteine to form the mixed disulfide cysteine-homocysteine. Most analytical procedures include a reduction step and do not distinguish between the reduced and various oxidized forms of homocysteine; thus, the analyte measured is referred to as homocyst(e)ine. The normal range is unclear but may fall between 5 and 15 mmol/L.
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عنوان ژورنال:
- Circulation
دوره 98 3 شماره
صفحات -
تاریخ انتشار 1998